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Histone-modifying enzymes and DNA methylationtargeting epigenetic drugs have shown promising results in clinical studies

Following an apoptotic stimulus, Bax is activated and translocates to the mitochondria, where it undergoes a conformational change and inserts into the OMM

Pyrshev et al

However, this extrapolation from one organ to another is questionable as the exposure levels, the phase I metabolic capacity to generate NAPQI, the phase II metabolic capacity to eliminate APAP, and potential adaptive mechanisms in response to an APAP-induced cellular stress are not well described in the CNS system

Ogle CK, Ogle JD, Mao JX, et al