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IL-23 is a member of the IL-12 family and coordinates with TGF- and IL-1 to upregulate the IL-23 receptor (IL-23R) during Th17 cell differentiation [22]

ROS produced by mitochondria oxidize proteins from complex I and II of the electron transport chain and negatively affect mitochondrial respiration

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60 AST-120 was studied in a phase-2, multicenter RCT that evaluated the efficacy and safety of AST-120 in the treatment of low-grade HE

However, considering GHKs high affinity for copper (see below) and essentiality of copper for cell growth, it is virtually impossible to have copper-free GHK in a living system