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These are two entirely separate biological domains

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Children with rare mutations in the CBS or MTR genes can have neural tube defects, early atherosclerosis, or neurological effects.[ref] Related article : MTHFR and the methylation cycle Sex, age, and smoking: Men tend to have higher homocysteine levels than women, and homocysteine levels in both sexes tend to increase slightly with age

Caffeine, nicotine, alcohol and stress all impact the skin, and excessive intake of processed foods, high-glycemic foods (high in refined sugars) and some types of fried foods can worsen conditions like acne

13 Other protocols for the use of glutathione, generally for age related disease, sometimes start intramuscular dosing at just 200mg per week and increase as tolerated up to a maximum of 1000mg per week