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It drives energy expenditure, accelerates fat metabolism in the liver, and appears to produce meaningfully greater weight loss than dual-agonist approaches

In fibrotic diseases, however, the calpain/calpastatin system is often dysregulated resulting in maladaptive hypertrophy and HF [18]

Gillison ML, Blumenschein G, Jr., and Fayette J, et al (2018) CheckMate 141: 1-year update and subgroup analysis of nivolumab as first-line therapy in patients with recurrent/metastatic head and neck cancer Oncologist 23 (9) 10791082 PMID: 29866947 PMCID: 6221824 6

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To model these interactions structurally using molecular docking and dynamics, the minimal requirement will be a validated homology model of OATP2B1