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Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden

Zepbound is FDA-approved for weight loss in adults with obesity or overweight who have a weight-related condition

CAG_38, Gemmiger formicilis , Clostridium leptum , and Asaccharobacter celatus [21]

GLP-1R agonists show promise in weight management however, challenges remain in enhancing their stability and effectiveness in the clinical setting due to natural degradation processes [79, 80]

however, in a large cardiovascular outcomes trial (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results [LEADER]), liraglutide 1.8 mg was associated with cardiovascular benefits