Semaglutide (also injected weekly) was associated with an average weight loss of around 11% after 24 to 68 weeks, with evidence suggesting the effect can persist for up to two years, based on 18 randomized controlled trials (27 949 participants)
All methods were carried out in accordance with relevant guidelines and regulations
GLP-1 receptors are found not only in the pancreas but also in immune cells, indicating that these medications can influence immune function
Although prospective studies specifically targeting PCOS + MASLD with pregnancy outcomes as the primary endpoint are currently lacking, a robust inference can be drawn based on the pathophysiological framework of MASLD and evidence from the general population: proactively identifying and reducing MASLD and ectopic fat load prior to pregnancy may be a key step in improving both periconception outcomes and long-term prognosis (68, 76)
This is a concern, particularly for those trying to improve their overall body composition or for individuals with diabetes, where muscle mass plays a vital role in insulin sensitivity
