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In this context, genetic transformation stands out as a promising strategy to improve key agronomic and quality traits, and greater effort should be directed toward generating more stable phenotypes

Low somatostatin receptor subtype 2, but not dopamine receptor subtype 2 expression predicts the lack of biochemical response of somatotropinomas to treatment with somatostatin analogs

These include neurodegeneration, frailty, osteoporosis, vasomotor dysfunction, hepatic steatosis, insulin resistance, pulmonary fibrosis, chronic kidney disease, and skeletal muscle dysfunction (47)

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Third, all steps must be performed in a one-pot operation for efficient synthesis 3,9