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4 GLP-1RAs (eg, tirzepatide, semaglutide, and liraglutide) are synthetic peptides that mimic endogenous GLP-1, and use of these therapies has expanded beyond their metabolic functions in type 2 diabetes and weight loss into other diseases due to their anti-inflammatory properties and their ability to modulate immune function

Phase 1: initiation and early escalation (weeks 1 to 8) During the first weeks, heart rate changes are generally minimal at starting doses

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Additionally, Code Bio, a T1D Fund portfolio company, has explored GLP-1 to target beta cells for targeted drug delivery

Key Takeaways Retatrutide is being studied as a triple agonist that targets GIP, GLP-1, and glucagon receptors