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Hyperalgesia and Allodynia: Cases of hyperalgesia and allodynia have been reported with opioid therapy of any duration (see WARNINGS)

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Pijnenburg, J

The therapeutic effects arise through three primary mechanisms: central appetite suppression via hypothalamic GLP-1R activation (reducing food intake by 20-35%), delayed gastric emptying through vagal pathways (enhancing satiety per meal), and glucose-dependent insulin secretion from pancreatic beta cells (improving glycemic control)

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