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Excess carnitine is excreted via the kidneys [9]

Reduced appetite and food noise

Animal experiments have demonstrated that high-fat diet downregulates tight junction protein expression (such as occludin and ZO-1), reduces mucus layer thickness, and increases intestinal permeability ( Metabolic endotoxemia refers to a state of chronically elevated circulating LPS levels caused by diet (particularly high-fat diet) ( This inflammatory state further damages intestinal barrier function, forming a vicious cycle

The energy necessary for the transport of these neurotransmitters into the secretory vesicles is provided by the proton gradient generated by the vacuolar H + -ATPase (V-ATPase)

Carnitine: an overview of its role in preventive medicine