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Weakness: Physical weakness, particularly in the muscles and limbs

The inhibition, which shows dose dependency, is exerted via interactions with receptors in the brain that are accessible via leaks in the blood-brain barrier of the circumventricular organs, mainly the postrema area, the subfornical organ and the median eminence [10, 11]

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Intramuscular injections are touted as being easier to administer than intravenous, partly because of the easy access of the thigh muscles

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