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Altered gut-brain signals: Semaglutide may change the way the gut and brain communicate, impacting appetite, nausea, and feelings of fullness

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Your doctor may prescribe a low dose of this medication and gradually increase it to reduce the possibility of side effects

So if you handled semaglutide well, there's a good chance you'll handle tirzepatide well too, especially with the slow dose escalation

Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on August 19th, 2025