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Semaglutide Injection: Clinical Evidence and Real-World Results Semaglutide, approved for weight management as Wegovy, demonstrated remarkable efficacy in the STEP clinical trial program, where participants receiving the highest dose lost an average of 17.4% of their starting body weight over 68 weeks

OG also ameliorated non-alcoholic fatty liver disease (NAFLD), as evidenced by reduced hepatic lipid accumulation and normalized adipose tissue metabolism

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Durability of effect: A large real-world head-to-head analysis presented at ASMBS 2025 found patients lost ~5 more weight at 2 years with sleeve or bypass than with semaglutide/tirzepatide (about 24% vs 4.77% ), reflecting high discontinuation and adherence challenges with weekly injections