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Mller TD, Finan B, Bloom SR, Alessio DD, Drucker DJ, Flatt PR, et al

CTLA-4 is an inhibitory receptor constitutively found on T cells that decreases T-cell function.1 Blockade of this inhibitor allows for antigen co-stimulation and broad T-cell activation.5 The CTLA-4 inhibitor ipilimumab was the first ICI approved, although it has limited single-agent activity in most cancers and is largely used in combination PD-1/PD-L1 blockade

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Yes, according to recent research

Modulation of insulin sensitivity by exercise training: implications for cardiovascular prevention