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In DPN, particularly omega-3s, demonstrate protective mechanisms through the anti-inflammatory effect, antioxidant pathways (mostly Nrf2 pathway), membrane stability and improved conduction velocity [113]

Recent progress and research trend of anti-cataract pharmacology therapy: a bibliometric analysis and literature review

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The destruction of the mitochondrial electron transport chain (ETC) leads to an increase in ROS production, which triggers matrix metalloproteinases (MMP) induction, ultimately disrupting tight junctions and increasing BBB permeability