It also acts as a localised 5-alpha reductase inhibitor, reducing DHT at the scalp level
Portincasa P, Moschetta A, Palasciano G (2006) Cholesterol gallstone disease
20 , 21 Much earlier, Selyes concept was born outside of the gastrointestinal tract, in the adrenal gland, and Selye conceptualized the general syndrome of adaptation (i.e., adrenal gland hypertrophy, thymolymphatic involution, and stomach stress ulcers) to achieve general homeostasis in the whole body while the derangement could explain the genesis of many stress-induced diseases
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The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation