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However, a retrospective analysis published in the Journal of Diabetes Science and Technology found GLP-1 receptor agonist use did not increase the risk for NAION compared with other non-GLP-1 drugs

The findings from this post hoc analysis of SUSTAIN 6 and PIONEER 6 reinforce the recommendation in the guidelines that GLP-1RAs should be used to reduce the risk of MACE across the spectrum of age, and offer an alternative approach to treatment de-escalation, as is currently advised by the ADA in adults 65 years [6], which should lead to better outcomes for older adults [1, 18, 22]

They are particularly beneficial for adults with obesity or related conditions such as type 2 diabetes or cardiovascular disease

According to the American Diabetes Association, metformin is often recommended as the first-line treatment for type 2 diabetes