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In trials, medication treatments may be more standardized and less influenced by sociocultural variables than lifestyle and surgical interventions

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Risk factors that increase this concern include: History of peptic ulcer disease or gastrointestinal bleeding Concurrent use of anticoagulants (warfarin, apixaban) or antiplatelet agents (aspirin, clopidogrel) Use of corticosteroids or selective serotonin reuptake inhibitors (SSRIs) Chronic alcohol consumption Presence of Helicobacter pylori infection For patients taking low-dose aspirin for cardiovascular protection, ibuprofen can interfere with aspirin's antiplatelet effect