The R380 7.35b Q substitution resulted in a more than 15-fold reduction in GLP-1 affinity and abolished potency (Yang et al., 2016), whereas R380 7.35b D lowered potency by 1850-fold, but affinity was only reduced by 21-fold, and R380 7.35b G decreased potency by 40-fold and affinity by fourfold
This only applies to those taking Mounjaro and is especially important for the four weeks after starting Mounjaro and after any dose increase Review (18 RCTs, n=27,949) found semaglutide results in a clinically relevant weight loss at mediumterm followup vs placebo, likely to be sustained in long term while on treatment
Total brain APP and A oligomer levels are reduced in Liraglutide-treated AD mice (147, 158160), and intervention with liraglutide can prevent tau hyperphosphorylation (161164)
You might experience constipation due to slower digestion and less food moving through your system
doi: 10.3390/medsci13040265, 7