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In pediatrics, most available studies do not stratify outcomes by sex, underscoring an important knowledge gap and the urgent need for research that addresses sex-specific responses during childhood and adolescence

van Bloemendaal L, RG IJ, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML et al

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36 Similar to the findings previously noted for the PIONEER 5 study, no differences were seen in any pharmacokinetic or safety parameters based on baseline kidney function, including participants receiving hemodialysis