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Sonne DP, Engstrom T, Treiman M: Protective effects of GLP-1 analogues exendin-4 and GLP-1(936) amide against ischemia-reperfusion injury in rat heart
It was, they thought, a recipe for a potential blockbuster of a diabetes drug
(Many people use Ozempic off label for weight loss, though it is not FDA-approved for such.) These medications seem to promote weight loss through two mechanisms that, again, mimic the action of endogenous GLP-1: They delay gastric emptying: The sensation of fullness caused by slower gastric emptying can prompt people to eat less, thus helping them lose weight over time
In fact, diabetes remains one of the leading causes of kidney failure in the United States