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Antioxidant Defense Glutathione peroxidases use glutathione to reduce peroxides and limit oxidative damage to proteins, membranes and mitochondria

Meanwhile, mechanisms provided by microbial metabolites and the local immune system restore normal mechanosensitivity

Moreover, HBED has passed Phase I in clinical trials and is shown to be safe to administer to humans (Grady et al., 1994

Recent investigations have shifted predominantly toward topical delivery systems, reflecting ongoing challenges with oral curcumin bioavailability despite enhancement strategies

Limitationa and perspectives Targeting ferroptosis appears to have a favorable impact on the clinical treatment of multiple human diseases