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Looking forward, enhancing the bioavailability and targeted delivery of polyphenols could open new avenues in drug development for metabolic disorders, dermatological applications, and the formation of functional foods aimed at improving physical performance and overall well-being

10.1002/2211-5463.12580 149 NasoohiS.SimaniL.KhodagholiF.NiksereshtS.FaiziM.NaderiN.et al

Many of the most common side effects (headaches, water retention) respond well to increased water intake, especially during the first few weeks

Evidence has summarized the risks associated with LC, indicating that an intake of 2 g or less per day is relatively safe for most people without causing severe side effects, whether long-term or acute

The GlyNAC combination (glycine + NAC) showed multi-system improvements in a 16-week RCT in older adults, including corrected glutathione deficiency, reduced oxidative stress, improved mitochondrial function, and enhanced physical performance