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Since a Cul3 haploinsufficient mouse model also showed an upregulation of RhoA expression, treatment using the RhoA inhibitor Rhosin was used to successfully rescue these phenotypes in vitro in primary cortical neuron cultures derived from these mice [34]

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When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

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Folic acid is a synthetic form of folate used in dietary supplements and fortified foods