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Despite these recommendations, there is limited real-world data evaluating outcomes of GLP1-RAs specifically in patients with moderate to advanced CKD or ESRD

Some patients describe the sensation as similar to early-stage side effects but exacerbatedand in some cases, severe enough to require medical support

Safety Winner: Semaglutide GLP-1 RAs in general have a lower side effect risk than tesamorelin, and the literature currently favors semaglutides safety profile over that of tirzepatide

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The study confirmed that the newly developed GLP-1/GIP/glucagon receptor triagonist was superior to previous dual receptor co-agonists with greater efficacy in decrease in body weight, reduction in lipid levels and a decrease in insulin secretion [58]