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Continued Refrigeration: You may also choose to put the pen back in the refrigerator after use

Lancet 2010;375:141012

Nausea is the most common side-effect GLP-1 symptom, followed by vomiting, sour burps, heartburn and gastroparesis Side-Effect Profile of GLP-1s, from Worst to Best (% reflects estimated number of patients with GI side-effects) 50% Semaglutide (Ozempic, Rybelsus, Wegovy) 40% Tirzepatide (Saxenda, Mounjaro) 40% Liraglutide (Victoza, Saxenda) 30% Lixisenatide (Adlyxin USA, Lyxumia UK) 10% Dulaglutide (Trulicity) 10% Exenatide (Byetta, Bydureon) Wegovy, Mounjaro, and Saxenda FDA-approved for weight loss

Additionally, GPER influences the expression of bone metabolism-associated genes such as Runx2 and osteocalcin through downstream signaling pathways, including cAMP/PKA and AMPK, promoting osteoblast activity and suppressing osteoclast-mediated bone resorption

& Roling, J