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Bacteria are always vulnerable to antimicrobial agents once they scatter out of biofilms, which indicates that the antibiotic resistance of bacteria in biofilms isnt acquired through mutations

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however, it entails the risk of offtarget effects, potentially leading to nonspecific DNA cleavage at other genomic loci and presenting potential immunogenicity concerns

In these patients the hyperkalemia is eventually resolved via the action of calcium-activated potassium channels (commonly referred to as big K + , BK channels or MaxiK channels) within the DCT