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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Nauck M.A., Meier J.J

Congress created the PTE mechanism in 1984, under the Drug Price Competition and Patent Term Restoration Act, commonly known as Hatch-Waxman, to restore some of that lost time

The inhibition was dose-dependent and described as noncompetitive, meaning copper didnt block the substrate directly, but rather altered the enzymes activity