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The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain

By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide

A decreased HoloTC level along with an increase in the size of the red blood cells (macrocytosis) is a good measure of vitamin B12 deficiency

The median increase of vitamin B12 levels in the non-responder group was 97 pmol/l (IQR: 78, 173) and in the responder group 934 pmol/l (IQR: 571, 1130)

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