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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury
doi: 10.1038/s41593-021-00975-6 390 XieX.MaG.LiX.ZhaoJ.ZhaoZ.ZengJ.et al
Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules) and antioxidants in your body
This makes the gut a logical place to begin
(16a) Many of the genes associated with AITD are also associated with other autoimmune diseases, which highlights a key role for disrupted T cell central tolerance, antigen monitoring and peripheral immune tolerance in autoimmune onset
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