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And above all, the Ex-4 modulates the tau hyperphosphorylation and cognitive dysfunction by raising the Ins2 -derived brain insulin via Wnt/-catenin/NeuroD1 pathway in T2DM (71)

In November 2010 the Food and Drug Administration began consultation with patient groups, physicians and industry on how to approve the first copies of these drugs, known as follow-on biologics or biosimilars