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In a classic study of an entire community, Tunbridge et al.(37) found that 1.9 - 2.7% of women had present or past thyrotoxicosis, 1.9% had overt hypothyroidism, 7.5% had elevated TSH levels, 10.3% had test results positive for TPO (microsomal antigen) Ab measured by hemagglutination assay (MCHA), and about 15.0% had goiter

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C4 (7- -hydroxy-4-cholesten-3-one) is positively associated with FGF19 and total BAs in IBS-D individuals, which indicates that the loss of BAs in feces leads to an increase in BA production