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Key Points Depression is one of the leading causes of disability worldwide

5 Challenges and future directions in microbiota-based interventions for hypothyroidism Although microbiota-targeted strategies present a promising adjunct in the management of hypothyroidism, several critical challenges must be addressed to fully realize their therapeutic potential (Figure 5)

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As gestation advances, the placenta becomes increasingly vulnerable to xenobiotic agents because of decreases in placental thickness and a reduction in the number of cell layers