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A strong letter of medical necessity should include: your BMI history over at least 12 months, documentation of weight-related comorbidities (hypertension, type 2 diabetes or prediabetes, dyslipidemia, sleep apnea), prior weight-loss attempts and their outcomes, the specific clinical trial data supporting the requested medication, and a statement that the medication is medically necessary (not cosmetic)

No reports of the palpitation, anxiety, or mood changes occasionally associated with BPC-157

These shifts may improve outcomes and justify larger trials testing durability beyond 32 weeks and generalizability, including effects on mortality benefits

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