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Combo versus conventional pharmacology NSAIDs (ibuprofen, diclofenac) reduce acute pain and inflammation but delay tissue repair by blocking the constructive inflammatory phase

The effective dosage of garlic has not been determined

In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion

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