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This dose has been shown in vivo to be protective in a gastric mucosal lesion model (25) and it has been shown to promote bone healing in rabbits (28)

This difference was likely attributable to the insufficient inhibition of excessive GJ proteins in hepsin / mice in response to the lower 2APB dose of 1 mg/kg, lending further support to the hypothesis that hepsin may help reduce APAP toxicity by regulating the expression of hepatic GJ proteins

CRH-deficient mice have a normal anorectic response to chronic stress