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In addition, chronic stimulation of VANs reduces food intake and weight gain in rats 45,46,47 and is associated with weight loss in humans 48 , highlighting the long-term physiological relevance of vagal signaling

Chronic Disease Prevention: Lowers the risk of chronic diseases such as heart disease, cancer, and neurodegenerative disorders

Stevenson LW, Bellil D, Grover-Mckay M et al (1987) Effects of afterload reduction (diuretics and vasodilators) on left ventricular volume and mitral regurgitation in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

For example, Treg cell-specific deletion of phosphatase and tensin homolog (PTEN) causes the hyperactivation of glycolysis and reduces FoxP3 stability, thereby impairing the suppression of Th1 cell and follicular helper T (Tfh) cell immune responses [153]