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A medically supervised program manages these proactively so patients dont self-discontinue or yo-yo dosing

Other serious adverse events can include severe nausea and vomiting leading to dehydration, acute kidney injury, particularly in patients with existing kidney disease, and diabetic retinopathy complications in some patients with diabetes

J Am Acad Dermatol 2012

Patients taking medications that promote weight gain (such as insulin, sulfonylureas, or certain antipsychotics) may experience attenuated weight loss, though glucose control typically improves regardless

The increased pigmentation provides a partial barrier to the penetration of UVR and visible light