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Mislocalized TDP-43 in neurons and glial cells disrupts RNA processing and proteostasis, leading to cellular dysfunction that contributes to pathological glial alterations and neurodegeneration

Ongoing monitoring ensures long-term safety and effectiveness Weight loss is not a static process

doi: 10.1002/art.22085 159 GarciaRJFrancisLDawoodMLaiZWFaraoneSVPerlA

The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects

Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives