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SUSTAIN-6, 2016 GLP-1 receptor signaling in the hypothalamus and hindbrain modulates satiety and food-reward pathways, a focus of ongoing neuroscience research

00:15:50 Vickie Danaher Whereas, again, oral semaglutide must be taken on an empty stomach with a very small amount of water, and then patients must wait 30 minutes before the first food, beverage, or other meds of the day

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While its rare for nausea to be severe, this means that the dose probably needs adjustment and it's important for that person to talk with their healthcare provider