Side effect profile and tolerance : Gastrointestinal adverse effectsparticularly nausea, vomiting, and reduced appetiteare the most common side effects of GLP-1 receptor agonists, especially during dose escalation
Physicians should avoid prescribing it to: Patients with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2). Individuals with severe gastrointestinal conditions, such as gastroparesis. Patients with a known allergy to GLP-1 receptor agonists. Pregnant or breastfeeding women, unless approved by a physician
108 In March 2015, the FDA required a black box warning on Tanzeum due to the observed risk of thyroid C-cell tumors in animals, although it is unclear if this effect also occurs in humans
BMI is a screen, not the final word
Journal Diabetes Research 2018 , Hou, Y., Ernst, S