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Major Congenital Malformations The NAAED Pregnancy Registry indicates an increased risk of major congenital malformations, including but not limited to oral clefts in infants exposed to topiramate during the first trimester of pregnancy

The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health and Social Care

Studies in fly models of PD treated with NAM, NAD + , or through PARP mutations demonstrated increased NAD + levels, which also rescued mitochondrial function 283,284,285

Lighezan L, Meiri D, Breiman A, Neagu A

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