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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Frandsen C.S., Dejgaard T.F., Holst J.J., Andersen H.U., Thorsteinsson B., Madsbad S

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This reduced absorption means older adults may require more frequent B12 injections to maintain optimal levels

In addition to Complex I inhibition in humans and animal models of temporal lobe epilepsy (TLE), the redox regulated TCA cycle enzymes aconitase and -ketoglutarate dehydrogenase have been shown to be inactivated following status epilepticus (SE) in rats (Malinska et al., 2010)

The modification was developed to help enhance the half-life of the protein and allow it to obstruct the normal FOXO4 function