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Growth and apoptosis Ex-4 significantly improves the survival of rat cortical neurons under oxygen/glucose deprivation (OGD) conditions through reduced apoptosis rates, increased expression of glucose-regulated protein 78, and decreased levels of C/EBP-homologous protein, indicating the role of Ex-4 in modulating unfolded protein response for protecting neurons from ischemic damage [56]

They also respond to weight, with excess body fat, particularly visceral fat, being one of the strongest drivers of elevated triglyceride levels

Think of it like sunburn

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Changes to thyroid meds might be needed to keep hormone levels right