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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Aksoy S, Szumlanski CL, Weinshilboum RM

Heres a precise, honest breakdown of whats confirmed: Phase 3 TRIUMPH-4 (Eli Lilly, December 2025): At the 12mg dose, participants lost an average of 28.7% of body weight at 68 weeks up to 71.2 lbs per person

The cellular and molecular mechanisms underlying vascular stiffening comprises endothelial stiffness/dysfunction, increased vascular tone, remodeling of extracellular matrix and dysfunction of adventitial and perivascular adipose tissue [108,109,110]

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