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RNK06138 reduces nuclear ERK5 and attenuates ERK5 Paradoxical activation Previous research has shown that ERK5 kinase inhibitors, including AX15836, can promote ERK5 nuclear translocation and activate ERK5 transcriptional activity, thus resulting in the paradoxical activation of kinase-independent functions upon pharmacological inhibition [40]

He talks about how it's effective and important, mentioning that it fueled the industrial revolution

Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen F-Q, Nicoletti F, Calverley PMA

Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

First, it directly inhibits the tyrosinase enzyme, which means less melanin gets produced in the first place