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Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

Front Behav Neurosci 2014;8:219

10.1002/jsfa.6936 14 BertschC.Ramirez-SueroM.Magnin-RobertM.LarignonP.ChongJ.Abou-MansourE.et al

4 The burden of MASLD is projected to increase exponentially, with anticipated rises of 21% and 63% in cases of MASLD and MASH, respectively