Adverse Event Reports for Compounded Semaglutide and Tirzepatide
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Severity and How Long Reactions Lasted The pivotal 68-week trial reported in the New England Journal of Medicine, which enrolled 1,961 adults, described nausea and diarrhea as the most common adverse events with semaglutide and characterized them as typically transient, mild-to-moderate in severity, and subsiding with time
Now, TRPV1 is also deeply involved in central sensitisation and hyperalgesia in fibromyalgia, so thats a mechanistically plausible connection