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Glutathione levels may gradually decline, and skin benefits may reduce over time.

10.1016/j.freeradbiomed.2022.05.003 20 FlorianS.WinglerK.SchmehlK.JacobaschG.KreuzerO

In addition, chitosan nanocarriers can directly deliver drugs to the lymphatic system through lymphatic targeting technology, increase local drug concentration and reduce systemic toxicity