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Several approaches have been explored, including targeting inflammasome activation, inhibiting caspase-1, employing anti-inflammatory agents, and modulating the gut microbiota and bile acid metabolism

FDA labeling advises renal-function monitoring when adverse reactions could lead to volume depletion, especially during treatment initiation or dose escalation

Animal studies indicate that unstable blood sugar levels impact brain chemistry and stress pathways, which in turn influence mood

Moreover, some of the impressive metabolic gains from bariatric surgeries have been ascribed to alterations in the secretory profile of gut hormones